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The pipecolate area of rapamycin structure looks essential for rapamycin-binding to FKBP12. This phase is necessary for even more binding of rapamycin to the mTOR kinase, which can be The main element enzyme in several Organic actions of rapamycin.[forty six]PARP16 can be a tail-anchored endoplasmic reticulum protein demanded for the PERK- and IRE1